Related Experiment Video
Updated: Sep 23, 2025

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
[A case of Peutz-Jeghers syndrome that developed triple cancers during the course]
Keishi Fujiwara1,2, Seiji Kawano2, Tatsuhiro Yamazaki2
1Department of Internal Medicine, Kousei Hospital.
Abstract:
At the time of colon polyp follow-up, a 46-year-old Japanese woman with a history of invagination, colon polyps, cervical cancer, and breast cancer was suspected of Peutz-Jeghers syndrome and referred. Multiple polyposes of the jejunum were discovered by capsule endoscopy and double-balloon endoscopy, and the resected specimen was diagnosed with hamartoma. During the follow-up, advanced pancreatic cancer-derived from IPMN developed. It is important to remember that multiple cancers can develop in Peutz-Jeghers syndrome.
Related Concept Videos
Cancers Originate from Somatic Mutations in a Single Cell
Cancer Prevention
Some...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Abnormal Proliferation
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer

