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Related Experiment Video

Updated: Sep 23, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Normal glymphatic system function in patients with migraine: A pilot study.

Dong Ah Lee1, Ho-Joon Lee2, Kang Min Park1

  • 1Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Headache
|May 13, 2022
PubMed
Summary
This summary is machine-generated.

This pilot study found no differences in glymphatic system function, assessed by diffusion tensor imaging analysis along the perivascular space (DTI-ALPS), between migraine patients and healthy controls. The DTI-ALPS method proved feasible for neurological disease research.

Keywords:
diffusion tensor imagingglymphatic systemmigraine

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Area of Science:

  • Neuroscience
  • Radiology
  • Neurology

Background:

  • The glymphatic system is crucial for brain waste clearance.
  • Glymphatic system dysfunction is implicated in various neurological disorders.
  • Its role in migraine pathophysiology remains largely unexplored.

Purpose of the Study:

  • To evaluate and compare glymphatic system function in migraine patients versus healthy controls.
  • To investigate differences in glymphatic function between migraine with and without aura.
  • To assess the feasibility of diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) in this context.

Main Methods:

  • Cross-sectional pilot study design.
  • Prospective enrollment of 92 migraine patients and 80 healthy controls.
  • Brain MRI including DTI-ALPS to calculate the ALPS index.
  • Statistical comparison of ALPS index between groups and correlation with clinical characteristics.

Main Results:

  • No significant differences in ALPS index between migraine patients and healthy controls (p=0.233).
  • No significant differences in ALPS index between migraine with and without aura (p=0.601).
  • No significant correlations between ALPS index and migraine clinical characteristics (age, onset, duration, frequency, intensity).

Conclusions:

  • Glymphatic system function appears preserved in patients with migraine.
  • No discernible differences in glymphatic function exist between migraine subtypes.
  • DTI-ALPS is a feasible method for researching glymphatic function in neurological diseases.