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Low levels of vitamin D and coronary artery disease: Is it time for therapy?

Monica Verdoia1,2, Rocco Gioscia1, Matteo Nardin3

  • 1Division of Cardiology, Ospedale degli Infermi, ASL Biella, Biella, Italy.

Kardiologia Polska
|May 13, 2022
PubMed

Insights

Vitamin D deficiency is common and linked to coronary artery disease (CAD). This review examines vitamin D

Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Growing prevalence of vitamin D deficiency (hypovitaminosis D) globally.
  • Established links between vitamin D levels and coronary artery disease (CAD) risk and severity.
  • Inconsistent findings regarding vitamin D supplementation efficacy in primary cardiovascular prevention.

Purpose of the Study:

  • To provide an updated review of evidence on vitamin D and CAD.
  • To explore potential therapeutic applications of vitamin D in patients with established CAD.
  • To address the importance of vitamin D in cardiovascular health.

Main Methods:

  • Comprehensive literature review of observational studies and meta-analyses.
  • Analysis of data on vitamin D association with CAD prevalence, severity, and ischemic events.
  • Evaluation of existing research on vitamin D supplementation in primary prevention and established CAD.

Main Results:

  • Consistent associations demonstrated between vitamin D status and CAD prevalence/severity.
  • Prognostic implications of vitamin D levels in cardiovascular health are significant.
  • Vitamin D supplementation trials show mixed results, particularly in primary prevention.

Conclusions:

  • Further research is needed to clarify the role of vitamin D in established CAD.
  • Optimization of vitamin D therapeutic strategies is crucial for cardiovascular health.
  • The review highlights the need for evidence-based guidelines for vitamin D use in CAD patients.

Keywords:
atherosclerosisinflammationpharmacological therapythrombosisvitamin D

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