Outcomes of Nephron-sparing Surgery in T1 vs T2 Renal Tumours

Area of Science:

• Urology
• Nephrology
• Oncology

Background:

• Renal tumours pose a significant clinical challenge.
• Nephron-sparing surgery is a common approach for renal tumours.
• Assessing functional outcomes post-surgery is crucial.

Purpose of the Study:

• To compare the impact of nephron-sparing surgery on estimated Glomerular Filtration Rate (eGFR) in patients with T1 versus T2 renal tumours.
• To evaluate differences in perioperative outcomes between T1 and T2 renal tumour surgeries.

Main Methods:

• Retrospective analysis of 87 patients undergoing nephron-sparing surgery between 2014-2019.
• Patients were stratified into T1 (≤7 cm) and T2 (>7 cm) renal tumour groups.
• Comparison of eGFR, blood transfusion requirements, hospital stay, and complications between groups.

Main Results:

• A significantly greater drop in eGFR was observed in the T2 tumour group compared to the T1 group at 1-year follow-up.
• T2 tumours were associated with increased perioperative complications, higher blood transfusion rates, and longer hospital stays.
• These findings highlight functional and morbidity differences based on tumour stage.

Conclusions:

• Nephron-sparing surgery for T2 renal tumours is associated with poorer eGFR preservation and increased perioperative morbidity compared to T1 tumours.
• The decision for extensive nephron-sparing surgery in T2 renal tumours should be individualized.
• This underscores the importance of balancing oncological control with renal function preservation.