Related Experiment Video
Updated: Sep 23, 2025
09:19
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
11.0K
Mesenchymal Stem Cells: New Alternatives for Nervous System Disorders
Miguel Antonio Jiménez-Acosta1, Lory Jhenifer Rochin Hernández1, Mayte Lizeth Padilla Cristerna1
1Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Instituto Politécnico Nacional 2508, 07360 México City, México.
Current Stem Cell Research & Therapy
|May 13, 2022
Summary
Mesenchymal stem cells (MSCs) show promise for treating neurological diseases due to their differentiation and regenerative properties. MSC transplantation may enhance recovery by reducing inflammation and promoting neurogenesis.
Area of Science:
- Stem cell biology
- Neuroscience
- Regenerative medicine
Background:
- Mesenchymal stem cells (MSCs) are multipotent stem cells residing in perivascular niches across postnatal tissues.
- MSCs possess multilineage differentiation potential (mesodermal, endodermal, ectodermal) and crucial trophic properties.
Approach:
- This review analyzes MSC transplantation studies for various neurological conditions.
- Investigated MSCs' role in treating demyelinating injury, spinal cord injury, Parkinson's, Alzheimer's, and cochlear injury.
Key Points:
- MSCs promote functional recovery in neurodegenerative diseases and nervous system injuries.
- Therapeutic effects are mediated by trophic factor secretion, immunomodulation, reduced apoptosis, and enhanced neurogenesis.
- Patient-derived MSCs offer a unique model for studying brain diseases, acting as a 'window to the brain.'
Conclusions:
- MSCs are promising therapeutic agents for neurological disorders, leveraging their regenerative and immunomodulatory capacities.
- Further research into MSC transplantation holds potential for advancing treatments for debilitating neurological conditions.
Keywords:
Mesenchymal stem cellscell-based therapyfunctional recoverynervous system disordersneurodegenerative diseasesneuronal differentiationtransplantationMore Related Videos
Related Concept Videos
01:19Mesenchymal Stem Cells
5.1K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.1K
01:17Stem Cell Culture
5.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.5K
01:22iPS Cell Differentiation
2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
01:21Stem Cell Therapy for Tissue Regeneration
4.2K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
00:58Embryonic Stem Cells
29.1K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
29.1K
01:15Neurogenesis and Regeneration of Nervous Tissue
1.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.1K