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COVID-19 Is Associated With a 4 Fold Increase in 30-day Mortality Risk in Hip Fracture Patients in the United

Saleem Mastan1, Ghazal Hodhody1, Mohammed Sajid1

  • 1Health Education North West, UK.

Geriatric Orthopaedic Surgery & Rehabilitation
|May 13, 2022
PubMed

Insights

Elderly hip fracture patients with COVID-19 infection faced a significantly higher mortality risk. This systematic review highlights the critical need to prevent coronavirus disease (COVID-19) infection in this vulnerable population.

Area of Science:

  • Geriatric Medicine
  • Infectious Diseases
  • Public Health

Background:

  • Hip fractures in the elderly are linked to substantial mortality.
  • The risk of death may be exacerbated by concurrent COVID-19 infection.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis on the impact of COVID-19 infection on mortality rates in UK hip fracture patients during the initial pandemic surge.
  • To quantify the mortality risk associated with COVID-19 in this patient cohort.

Main Methods:

  • A systematic literature search was performed across 9 databases following Cochrane methodology.
  • 10 studies involving 2448 hip fracture patients met the eligibility criteria.
  • Meta-analysis utilized a random-effects model to assess mortality differences.

Main Results:

  • Patients with laboratory-confirmed COVID-19 had a mortality rate of 32.5% versus 8.6% in COVID-19 negative patients.
  • A 4-fold increased mortality risk was observed in hip fracture patients with confirmed COVID-19 compared to uninfected patients (RR=3.937).
  • Similar increased risks were found when comparing laboratory-confirmed or clinically suspected COVID-19 cases to non-infected patients (RR=4.576).

Conclusions:

  • COVID-19 infection is associated with a four-fold increase in mortality risk among hip fracture patients.
  • Preventing COVID-19 infection and nosocomial exposure is crucial for this high-risk group.
Abstract

Keywords:
Covid-19Hip fractureMeta-analysisMortality

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