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Updated: Sep 23, 2025

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
A complex interprofessional intervention to improve the management of painful procedures in neonates
Colette Balice-Bourgois1,2,3, Christopher J Newman4, Giacomo D Simonetti1,5
1Ente Ospedaliero Cantonale Pediatric Institute of Southern Switzerland Bellinzona Switzerland.
Insights
Developing NEODOL©, a new intervention, addresses undertreated procedural pain in newborns. This evidence-based approach involves healthcare professionals, parents, and neonates to improve pain management and translate research into practice.
Area of Science:
- Neonatal care
- Pain management
- Healthcare intervention development
Background:
- Neonates in hospitals experience significant procedural pain, leading to potential complications.
- Despite guidelines, neonatal procedural pain is often undertreated due to implementation gaps and time constraints.
- Effective pain management is crucial for neonatal well-being and development.
Purpose of the Study:
- To describe the development of NEODOL© (NEOnato DOLore), a complex interprofessional intervention to enhance procedural pain management in neonates.
- To outline the application of the Medical Research Council (MRC) framework and CReDECI 2 reporting criteria in intervention design.
- To evaluate the intervention's content and feasibility through expert and stakeholder consensus.
Main Methods:
- Utilized the MRC framework for complex intervention development and CReDECI 2 for reporting.
- Employed a multimethod approach, including a Delphi method with 16 panelists (experts, stakeholders, parents).
- Focused on developing a three-group intervention (healthcare professionals, parents, neonates) for a level IIb neonatal unit.
Main Results:
- The NEODOL© intervention was systematically developed following established guidelines.
- The Delphi process achieved consensus, with panelists deeming the NEODOL© intervention important and feasible.
- The intervention integrates theoretical bases, stakeholder input, and practical components for improved neonatal pain management.
Conclusions:
- NEODOL© is a well-developed, complex interprofessional intervention designed to improve the management of procedural pain in neonates.
- The intervention shows potential for bridging the gap between neonatal pain research and clinical practice.
- Successful implementation of NEODOL© could significantly enhance the quality of care for hospitalized neonates experiencing painful procedures.
Abstract:
During hospitalization, neonates are exposed to a stressful environment and a high number of painful procedures. If pain is not treated adequately, short- and long-term complications may develop. Despite evidence about neonatal pain and available guidelines, procedural pain remains undertreated. This gap between research and practice is mostly due to limited implementation of evidence-based knowledge and time constraints. This study describes in detail the development process of a complex interprofessional intervention to improve the management of procedural pain in neonates called NEODOL© (NEOnato DOLore). The framework of the Medical Research Council (MRC) for the development and evaluation of complex interventions was used as a methodological guide for the design of the NEODOL© intervention. The development of the intervention is based on several steps and multiple methods. To report this process, we used the Criteria for Reporting the Development of Complex Interventions in Healthcare (CReDECI 2). Additionally, we evaluated the content of the intervention using a Delphi method to obtain consensus from experts, stakeholders, and parents. The complex interprofessional intervention, NEODOL©, is developed and designed for three groups: healthcare professionals, parents, and neonates for a level IIb neonatal unit at a regional hospital in southern Switzerland. A total of 16 panelists participated in the Delphi process. At the end of the Delphi process, the panelists endorsed the NEODOL© intervention as important and feasible. Following the MRC guidelines, a multimethod process was used to develop a complex interprofessional intervention to improve the management of painful procedures in newborns. Complex interprofessional interventions need theoretical bases, careful development, and integration of stakeholders to provide a comprehensive approach. The NEODOL intervention consists of promising components and has the potential to improve the management of painful procedures and should facilitate the knowledge translation into practice.
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