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Published on: December 2, 2015
Early deviant behaviour as a dimension trait and endophenotype in schizophrenia
Johannes L Roos1,2, Carla Kotzé1,2
1Department of Psychiatry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Background:
In psychiatry, there is still a lack of objective biological diagnostic measurements. It is important to investigate measurements or symptom dimensions that can inform diagnostic assessments and allow for a more personalised approach to patients.
Aim:
To discuss how early deviant behaviour (EDB) may be seen as a possible continuous symptom dimension trait and endophenotype in schizophrenia.
Methods:
Conducting a commentary review by highlighting some important findings from available literature.
Results:
Findings regarding EDB in schizophrenia in a South African genetic sample point towards EDB as a progressive subtype of schizophrenia, with very early onset of illness (even prior to the psychotic symptomatology) and a genetic form of illness.
Conclusion:
Valuable information can be gained by enquiring into EDB and viewing it as a continuous symptom dimension trait and endophenotype during the psychiatric diagnostic interview.
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