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Coronavirus

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...

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Related Experiment Video

Updated: Jun 14, 2026

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System

Published on: April 6, 2021

Molecular and Serologic Diagnostic Technologies for SARS-CoV-2.

Halie M Rando¹, Christian Brueffer², Ronan Lordan³

¹Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America; Center for Health AI, University of Colorado School of Medicine, Aurora, Colorado, United States of America · Funded by the Gordon and Betty Moore Foundation (GBMF 4552); the National Human Genome Research Institute (R01 HG010067).

|May 13, 2022

Summary

Biotechnology advanced COVID-19 diagnostics, with molecular tests detecting active infections and serological tests identifying past exposure to SARS-CoV-2. These crucial tools aid in managing the pandemic by understanding viral spread.

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Last Updated: Jun 14, 2026

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System

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Published on: April 6, 2021

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Published on: February 16, 2022

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

Area of Science:

Biotechnology and Biomedical Science
Infectious Disease Research
Public Health

Background:

The COVID-19 pandemic necessitated rapid advancements in diagnostic technologies.
Effective management of viral threats relies on accurate detection of infected and recovered individuals.

Approach:

This review categorizes diagnostic tests for SARS-CoV-2 into molecular and serological methods.
It examines the biotechnological approaches within each category, highlighting their respective advantages and disadvantages.
The role of these diagnostics in understanding and controlling the COVID-19 pandemic is discussed.

Key Points:

Molecular diagnostics identify current infections by detecting the presence of the SARS-CoV-2 virus.
Serological tests detect antibodies, indicating a past immune response and previous exposure to SARS-CoV-2.
Both test types offer distinct, valuable information for epidemiological surveillance.

Conclusions:

Biotechnological innovations in diagnostics are critical for pandemic response.
Understanding the capabilities of molecular and serological tests is essential for effective COVID-19 management.
Continued development of sensitive and specific diagnostic tools remains a priority.