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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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The Causal Association Between Obesity and Primary Open-Angle Glaucoma: A Two-Sample Mendelian Randomization Study.

Yi Lin1, Xiaomin Zhu1, Wangdu Luo1

  • 1Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in Genetics
|May 13, 2022
PubMed
Summary

Obesity, including body mass index and hip circumference, significantly increases the risk of primary open-angle glaucoma (POAG). This Mendelian randomization study provides evidence for a causal link, aiding POAG prevention strategies.

Keywords:
Mendelian randomizationbody mass indexhip circumferenceprimary open-angle glaucomawaist circumference

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Area of Science:

  • Ophthalmology
  • Genetics
  • Public Health

Background:

  • The relationship between obesity and primary open-angle glaucoma (POAG) requires further clarification.
  • Obesity is a growing global health concern with potential systemic implications.

Purpose of the Study:

  • To investigate the potential causal effect of obesity on the risk of developing primary open-angle glaucoma (POAG).
  • To utilize a two-sample Mendelian randomization approach to assess this relationship.

Main Methods:

  • Employed a two-sample Mendelian randomization (MR) study design.
  • Utilized summary data from genome-wide association studies (GWAS) for body mass index (BMI), waist, and hip circumference (exposures) and POAG (outcome).
  • Applied inverse variance-weighted (IVW) and other MR methods for causal inference, with sensitivity analyses to ensure robustness.

Main Results:

  • A 1 SD increase in BMI was associated with a 90.9% increase in POAG risk (IVW method).
  • A 1 SD increase in hip circumference was associated with a 119% increase in POAG risk (IVW method).
  • Waist circumference also showed a positive association with POAG risk (weighted median method).

Conclusions:

  • This study provides novel evidence suggesting that obesity, indicated by BMI and hip circumference, is causally linked to an increased risk of POAG.
  • Findings may inform public health initiatives and clinical strategies for POAG prevention and management.
  • Highlights the importance of weight management in ocular health.