Cyclodextrin modified niosomes to encapsulate hydrophilic compounds

Area of Science:

• Materials Science
• Nanotechnology
• Physical Chemistry

Background:

• Niosomes are non-ionic surfactant vesicles used for encapsulation.
• Cyclodextrins (CDs) can modify vesicular properties and drug delivery.
• Azo dyes like methyl orange (MO) and methyl yellow (MY) serve as probes for hydrophobicity.

Purpose of the Study:

• To investigate the effect of beta-cyclodextrin (β-CD) and modified beta-cyclodextrin (Mod-β-CD) on niosome encapsulation efficiency and dye release.
• To understand the interaction of MO and MY with niosomes and CDs.
• To characterize the structural changes in niosomes upon CD incorporation.

Main Methods:

• Preparation of niosomes from Span 80 and Tween 80.
• Encapsulation of methyl orange (MO) and methyl yellow (MY) azo dyes.
• Addition of β-CD or Mod-β-CD to niosomes.
• Analysis of vesicle size, morphology, entrapment efficiency (EE), and dye release kinetics.
• UV-visible spectrophotometry and induced circular dichroism (ICD) for interaction studies.

Main Results:

• Mod-β-CD incorporation reduced niosome size and surface charge.
• Niosomes showed higher EE for MY than MO without CDs.
• β-CD significantly increased MO encapsulation and accelerated its release.
• MO complexed with CDs inside vesicles, while MY interacted with the niosome bilayer.

Conclusions:

• Mod-β-CD alters niosome structure, impacting dye encapsulation and release.
• MO interaction with niosomes is modulated by β-CD complexation.
• The study elucidates the differential interactions of MO and MY with niosomes and CDs, offering insights for targeted delivery systems.