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Intracerebral Hemorrhage: The Effects of Aging on Brain Injury

Noah Watson1, Frederick Bonsack1, Sangeetha Sukumari-Ramesh1

  • 1Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, United States.

Frontiers in Aging Neuroscience
|May 13, 2022
PubMed

Insights

Intracerebral hemorrhage (ICH) significantly impacts aging brains, yet research often overlooks older subjects. Understanding age-related changes is crucial for developing effective ICH treatments.

Area of Science:

  • Neurology
  • Gerontology
  • Neuroscience

Background:

  • Intracerebral hemorrhage (ICH) is a severe stroke type with high mortality and morbidity.
  • ICH survivors frequently experience lasting neurological deficits, hindering functional recovery.
  • Lack of understanding of ICH pathology limits therapeutic development.

Purpose of the Study:

  • To review the impact of advanced age on brain injury and recovery after ICH.
  • To identify knowledge gaps in aging-related ICH research.
  • To emphasize the need for studies in aged animal models.

Main Methods:

  • Literature review focusing on age-related effects in intracerebral hemorrhage.
  • Analysis of existing preclinical studies and their limitations regarding age.
  • Identification of molecular and cellular changes in aging brains post-ICH.

Main Results:

  • Advanced age is a significant risk factor for ICH.
  • Preclinical ICH research predominantly uses young animal models, not reflecting aging populations.
  • Molecular changes in aging brains following ICH remain largely uncharacterized.

Conclusions:

  • Current preclinical models inadequately represent the aging brain's response to ICH.
  • Further investigation into age-specific ICH pathology is essential for translational research.
  • Addressing these knowledge gaps may improve therapeutic strategies for elderly ICH patients.

Keywords:
agingintracerebral hemorrhageironmicroglianeuroinflammation

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