Activatable NIR-II organic fluorescent probes for bioimaging

Area of Science:

• Biomedical Optics
• Molecular Imaging
• Nanotechnology

Background:

• Near-infrared II (NIR-II) imaging offers deep tissue visualization with high resolution.
• Activatable fluorescence probes are crucial for reporting pathological changes.
• Organic fluorescent probes show significant advancements in NIR-II imaging.

Purpose of the Study:

• To review the design, synthesis, and applications of activatable NIR-II fluorescence probes.
• To highlight the potential of these probes for noninvasive pathological inspection.
• To discuss the prospects of NIR-II imaging for clinical translation.

Main Methods:

• Review of recent literature on activatable NIR-II fluorescence probes.
• Analysis of probe design strategies and synthetic approaches.
• Evaluation of probe performance in imaging various biomarkers.

Main Results:

• Activatable NIR-II probes exhibit tunable physicochemical and optical properties.
• These probes demonstrate excellent biocompatibility and processability.
• Applications include imaging reactive oxygen species (ROS), pH, hypoxia, and enzymes.

Conclusions:

• Activatable NIR-II fluorescence probes are powerful tools for noninvasive deep tissue imaging.
• Their versatility in detecting diverse pathological markers is highlighted.
• The technology shows significant promise for future clinical applications.