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Related Experiment Video

Updated: Sep 23, 2025

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Macrotrabecular-Massive Hepatocellular Carcinoma: What Should We Know?

Xiaoming Li1,2, Qiandong Yao3, Chen Liu1

  • 1Department of Radiology, Southwest Hospital, Third Military Medical University (Army Military Medical University), Chongqing, People's Republic of China.

Journal of Hepatocellular Carcinoma
|May 13, 2022
PubMed
Summary

Macrotrabecular-massive hepatocellular carcinoma (MTM-HCC) is a newly identified subtype linked to aggressive cancer. Early diagnosis via imaging, like MRI or CT, aids in predicting recurrence and improving patient outcomes.

Keywords:
gene mutationhepatocellular carcinomamacrotrabecular-massivemagnetic resonance imagingmolecular subclass

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Area of Science:

  • Hepatobiliary pathology
  • Oncology
  • Diagnostic imaging

Background:

  • Hepatocellular carcinoma (HCC) is a prevalent global malignancy.
  • A distinct histological subtype, macrotrabecular-massive HCC (MTM-HCC), exhibits aggressive behavior.
  • MTM-HCC is increasingly recognized for its prognostic significance.

Purpose of the Study:

  • To highlight the clinical significance of MTM-HCC.
  • To explore MTM-HCC's association with prognostic factors and molecular characteristics.
  • To investigate the role of preoperative imaging in MTM-HCC diagnosis.

Main Methods:

  • Review of histological findings and clinical data.
  • Correlation of MTM-HCC with molecular subclasses and gene mutations.
  • Analysis of preoperative imaging (Gd-EOB-DTPA enhanced MRI/CT) for diagnostic clues.

Main Results:

  • MTM-HCC is a strong independent predictor of early and overall recurrence.
  • Intratumor necrosis or ischemia on enhanced MRI/CT is an independent predictor for MTM-HCC.
  • MTM-HCC is linked to specific tumor molecular subclasses, gene mutations, and immunohistochemical markers.

Conclusions:

  • MTM-HCC is an aggressive histological subtype of hepatocellular carcinoma.
  • Preoperative imaging findings, such as necrosis/ischemia on MRI/CT, can suggest MTM-HCC.
  • Early diagnosis and tailored treatment of MTM-HCC are crucial for preventing recurrence and improving patient outcomes.