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Updated: Sep 23, 2025

Particles without a Box: Brush-first Synthesis of Photodegradable PEG Star Polymers under Ambient Conditions
Published on: October 10, 2013
Synthesis of well-defined star, star-block, and miktoarm star biodegradable polymers based on PLLA and PCL by one-pot
Xiaoqi Yan1, Jianbo Li1, Tianbin Ren1
1Institute of Nano and Biopolymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials, Ministry of Education, Tongji University 4800 Caoan Road Shanghai 201804 China lijianbo@tongji.edu.cn +86-21-33515906 +86-21-33515906.
Abstract:
Based on the "arm-first" strategy, ring-opening polymerization (ROP) and one-pot azide-alkyne click reaction, well-defined star-shaped polymers with different architectures have been successfully synthesized, including the star homopolymers four-arm star-shaped polycaprolactone (4sPCL) and four-arm star-shaped poly(l-lactic acid) (4sPLLA), star-block copolymer 4sPCL-b-PLLA and miktoarm star-shaped copolymer PCL2PLLA2. The star homopolymers 4sPCL and 4sPLLA were synthesized by a click reaction of an azide small molecule initiator and HC[triple bond, length as m-dash]C-PCL or HC[triple bond, length as m-dash]C-PLLA. The star-block copolymer 4sPCL-b-PLLA was synthesized by a click reaction of an azide small molecule initiator and the block copolymer HC[triple bond, length as m-dash]C-PCL-b-PLLA. The miktoarm star polymer PCL2PLLA2 was synthesized by a one-pot azide-alkyne click reaction of simultaneous addition of equal proportions of HC[triple bond, length as m-dash]C-PCL and HC[triple bond, length as m-dash]C-PLLA. The structures of these star-shaped polymers have been confirmed by NMR, FT-IR and GPC. Furthermore, the melting and crystallization behaviors investigated using DSC and WXRD also confirm the formation of star-shaped polymers with different architectures.
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