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Association of Office and Ambulatory Blood Pressure with Left Ventricular Structure and Function in Hypertensive

Zhuo Sang1, Xianli Zeng1, Xiaohui Yuan1

  • 1Department of General Practice, Huizhou Municipal Central Hospital, Huizhou, Guangdong, People's Republic of China.

International Journal of General Medicine
|May 13, 2022
PubMed

Insights

Twenty-four-hour ambulatory blood pressure (ABP) better reflects left ventricular (LV) changes in hypertensive patients than office blood pressure (OBP). These associations are stronger in men, highlighting sex-specific differences in hypertension management.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Cardiovascular Imaging

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Left ventricular (LV) structure and function are key indicators of cardiovascular health.
  • Office blood pressure (OBP) may not fully capture the cardiovascular risk associated with hypertension.

Purpose of the Study:

  • To evaluate the association of OBP and 24-hour ambulatory blood pressure (ABP) with LV structure and function in hypertensive patients.
  • To determine if sex modifies the association between blood pressure measurements and LV alterations.

Main Methods:

  • Retrospective analysis of 694 hypertensive patients without cardiovascular disease.
  • Regression analysis to assess associations between OBP/ABP parameters and LV mass index (LVMi), e' velocity, and LV hypertrophy (LVH).
  • Adjustments for covariates including age, obesity, diabetes, OSA, eGFR, and antihypertensive medications.

Main Results:

  • Men exhibited higher 24h, daytime, and nighttime SBP than women, along with a greater prevalence of non-dipping and reverse dipping patterns.
  • 24h, daytime, and nighttime SBP, along with non-dipping and reverse dipping patterns, were associated with LVMi, e' velocity, and LVH in overall participants.
  • These associations were not observed with OBP.
  • The magnitude of these associations was significantly stronger in men compared to women.

Conclusions:

  • 24-hour ABP is superior to OBP in reflecting LV structural and functional alterations in hypertensive individuals.
  • Sex significantly modifies the association between ABP and LV alterations, with stronger links observed in men.
Abstract

Keywords:
ambulatory blood pressurecardiac functioncardiac structureoffice blood pressuresex

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