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Updated: Sep 23, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

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Association Between Plasma Lipoprotein Levels and Aortic Valve Calcification Among Patients with Aortic Valve

Tingting Tao1, Junnan Zheng1, Yu Han1

  • 1Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.

International Journal of General Medicine
|May 13, 2022
PubMed

Insights

Elevated total cholesterol is a risk factor for calcific aortic valve disease (CAVD), alongside age and mean transaortic gradient. Patients with aortic valve calcification (AVC) experienced worse one-year outcomes.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Calcific aortic valve disease (CAVD) is a common valvular heart condition.
  • The link between dyslipidemia and CAVD is not fully understood.

Purpose of the Study:

  • To investigate the association between plasma lipoprotein levels and aortic valve calcification (AVC) in patients undergoing aortic valve replacement.
  • To identify risk factors and outcomes associated with AVC.

Main Methods:

  • Retrospective analysis of 449 patients who underwent aortic valve replacement.
  • Categorization into aortic valve calcification (AVC) and non-calcification groups.
  • Logistic regression analysis of preoperative and one-year postoperative data, including lipoprotein levels and echocardiographic parameters.

Main Results:

  • AVC patients had higher rates of coronary heart disease, peripheral vascular disease, and heart failure preoperatively.
  • Significantly higher total cholesterol and very low-density cholesterol levels were observed in the AVC group.
  • Age, total cholesterol, and mean transaortic gradient were identified as AVC risk factors, while a larger aortic valve area was protective. One-year mortality and perivalvular leakage were higher in the AVC group.

Conclusions:

  • Elevated total cholesterol, along with age and mean transaortic gradient, are significant risk factors for AVC.
  • AVC is associated with poorer short-term outcomes, including increased mortality and complications.
Abstract

Keywords:
aortic valve calcificationaortic valve replacementlow-density lipoproteinplasma lipoprotein levelstotal cholesterol

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