Related Experiment Video
Updated: Sep 23, 2025

Synthesis of Compound Giant Unilamellar Vesicles: A Biomimetic Model of Nucleate Cells
Published on: July 3, 2025
Giant Polymer Vesicles with a Latticelike Membrane
Xinyue Zhang1,2, Qiutong Huang2, Fangyingkai Wang2
1Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China.
Abstract:
Hierarchical self-assembly offers great possibilities to mimic biological systems with finely arranged complex structures. Herein, we demonstrate the preparation and formation mechanism of an unusual giant polymer vesicle with a latticelike membrane (GVLM). This GVLM is formed by fusion-induced particle assembly (FIPA) of small vesicles that are self-assembled from poly(ethylene oxide)-block-poly[(2-(tetrahydrofuranyloxy)ethyl methacrylate)-stat-(6-(3,3-diphenylnaphthopyranyloxy)hexyl methacrylate)] [PEO43-b-P(TMA22-stat-NMA4)]. Flexible TMA units with high chain mobility and relatively rigid NMA units with intrinsic π-π stacking form the hydrophobic block. These units act as "antifusion" and "profusion" components, respectively. The latticelike membrane of the final GVLM consists of hundreds of small polymer vesicles that are interconnected via multiple interactions. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) studies show that the diameter of the GVLMs is 800-1000 nm. Overall, we provide a new insight into the judicious preparation of hierarchical nanostructures via chemical synthesis and FIPA.
Related Concept Videos
Clathrin Coated Vesicles
Intralumenal Vesicles and Multivesicular Bodies
Vesicular Tubular Clusters
With the help of motor proteins such...
COP Coated Vesicles
Fusion of Secretory Vesicles with the Plasma Membrane
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
Overview of Secretory Vesicles
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...

