Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

1.1K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
1.1K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

4.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
4.2K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

74.5K
Overview
74.5K
Development of Immunocompetence01:22

Development of Immunocompetence

467
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
467
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

7.7K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ancestry Matters in Decoding Immunity.

Immunology and cell biology·2026
Same author

A temporal map of B cell diversification mechanisms in mice.

Nature immunology·2026
Same author

Heterogeneity and dynamics of DENV-specific CD8 + T cells in dengue infection.

Nature communications·2026
Same author

A Hormone Cell Atlas maps the human endocrine system at cellular resolution.

Science (New York, N.Y.)·2026
Same author

Coupling dead cell recognition to Fcγ receptors augments anticancer immunity.

Nature cancer·2026
Same author

The GFI1-FOXO1 axis regulates NK cell maturation and function.

Nature communications·2026
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Sep 23, 2025

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

7.8K

Mapping the developing human immune system across organs.

Chenqu Suo1,2, Emma Dann1, Issac Goh3

  • 1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

Science (New York, N.Y.)
|May 13, 2022
PubMed
Summary
This summary is machine-generated.

This study maps the developing human immune system across nine prenatal tissues using advanced single-cell genomics. It reveals immune cell maturation timelines and origins beyond traditional hematopoietic organs, offering insights for regenerative medicine.

More Related Videos

Derivation of a Human Brain Organoid with Microglia Development
10:34

Derivation of a Human Brain Organoid with Microglia Development

Published on: January 17, 2025

1.2K
Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

11.0K

Related Experiment Videos

Last Updated: Sep 23, 2025

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

7.8K
Derivation of a Human Brain Organoid with Microglia Development
10:34

Derivation of a Human Brain Organoid with Microglia Development

Published on: January 17, 2025

1.2K
Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

11.0K

Area of Science:

  • Developmental biology
  • Immunology
  • Genomics

Background:

  • Previous single-cell studies mapped immune cells in specific prenatal organs.
  • These studies were limited in depicting the immune system as a distributed network across tissues.

Purpose of the Study:

  • To reconstruct the developing human immune system as a distributed network.
  • To characterize immune cell development and function in prenatal tissues.

Main Methods:

  • Profiling nine prenatal tissues using single-cell RNA sequencing.
  • Utilizing antigen-receptor sequencing and spatial transcriptomics.
  • Integrating multi-omic data for system-wide reconstruction.

Main Results:

  • Identified late acquisition of immune-effector functions by myeloid and lymphoid cells.
  • Revealed maturation of monocytes and T cells prior to peripheral tissue seeding.
  • Uncovered prenatal immune cell development beyond primary hematopoietic organs, including human B1 cells and unconventional T cell origins.

Conclusions:

  • The developed atlas provides comprehensive data and biological insights into the prenatal immune system.
  • Findings facilitate advancements in cell engineering, regenerative medicine, and disease understanding.
  • Highlights the importance of a systems-level approach to studying immune development.