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Updated: Sep 23, 2025

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Nup50 plays more than one instrument.

Guillaume Holzer1, Wolfram Antonin1

  • 1Institute of Biochemistry and Molecular Cell Biology, Medical School, RWTH Aachen University, Aachen, Germany.

Cell Cycle (Georgetown, Tex.)
|May 13, 2022
PubMed
Summary

Nuclear pore protein Nup50 interacts with and stimulates RCC1, a key factor in nuclear transport. This interaction influences Nup50

Keywords:
DNA repairNup50RCC1cell cyclenuclear pore assemblynuclear traffickingp27Kip1

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Nup50 is a nuclear pore complex component.
  • Nup50 functions as an auxiliary factor in nuclear transport.
  • RCC1 is the guanine nucleotide exchange factor for the GTPase Ran.

Purpose of the Study:

  • To discuss how Nup50's interaction with RCC1 contributes to its functions.
  • To explore Nup50's roles beyond nuclear transport.

Main Methods:

  • Interaction studies between Nup50 and RCC1.
  • Functional assays to assess Nup50's roles.

Main Results:

  • Nup50 interacts with and stimulates RCC1.
  • This interaction is proposed to impact Nup50's functions in nuclear transport, gene expression, cell cycle, and DNA repair.

Conclusions:

  • Nup50's interaction with RCC1 is crucial for its diverse cellular roles.
  • Nup50 plays a significant role in regulating nuclear transport, gene expression, cell cycle, and DNA damage repair.