Toward Early Diagnosis of Colorectal Cancer: Focus on Optical Nano Biosensors
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Published on: March 25, 2019
Mahdieh Darroudi1,2, Kousar Ghasemi3, Majid Rezayi2,4,5
1Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Background:
Colorectal cancer is a leading cause of death among cancers worldwide, with the symptoms mimicking other far more common lower gastrointestinal disorders.
Objective:
This challenge in separating colorectal cancer from other diseases has driven researchers to investigate a noninvasive screening technique and effective method. The early detection of colorectal cancer is imperative. Biomarkers play a critical role in colorectal screening tests, treatment, clinical and prognosis management. Therefore, sensitive and rapid biomarker detection would be helpful and demand the early diagnosis of colorectal cancer.
Methods:
Recently, several investigations have been performed to design biosensors for early detection of cancer diagnosis and profiling with strong applied ability and high sensitivity.
Results:
In comparison, optical biosensors are one of the promising platforms for the costeffective and rapid detection of biomarkers. This review will focus on the advancements and progress of the various optical-transducing approaches for diagnosing colorectal cancer.
Conclusion:
Further, the prospects and limitations of these optical biosensors in colorectal cancer diagnosis will be discussed. Here, an overview of optical biosensors and meaningful information for scientists worldwide will be demonstrated.
