Related Experiment Video

Updated: Sep 23, 2025

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
07:50

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues

Published on: January 7, 2019

7.0K

Clinical profile and one-year outcomes of patients with mural infective endocarditis: - A tertiary care centre study

Gopalan Nair Rajesh1, Haridasan Vellani1, Jomy Vadasseril Jose1

  • 1Department of Cardiology, Government Medical College, Kozhikode, Kerala, India.

Indian Heart Journal
|May 13, 2022
PubMed

Insights

Mural endocarditis, a rare form of infective endocarditis, presents with similar mortality and morbidity to valvular endocarditis. This study highlights its unique clinical features and outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Internal Medicine

Background:

  • Infective endocarditis (IE) rarely involves the mural endocardium, with limited comparative studies available.
  • Existing research primarily focuses on valvular or device-related IE, leaving mural endocarditis understudied.

Purpose of the Study:

  • To compare the clinical features, microbiological profiles, and clinical course of mural endocarditis with valvular endocarditis.
  • To elucidate the characteristics and outcomes of this rare IE manifestation.

Main Methods:

  • Retrospective analysis of a registry of infective endocarditis patients (April 2012 - April 2019).
  • Comparison of patients with mural endocardial vegetations against those with valvular/device IE.
  • Analysis of clinical data, laboratory parameters (ESR, CRP), microbiology, and outcomes.

Main Results:

  • Mural endocarditis identified in 5.38% of IE patients; ventricles were the most common site.
  • Lower inflammatory markers (ESR, CRP) and higher culture positivity (Staphylococcus Aureus) observed in mural IE.
  • Similar in-hospital mortality and embolic complication rates, including neurological events, were noted for mural IE.

Conclusions:

  • Mural endocarditis is a rare entity with comparable morbidity and mortality to valvular endocarditis.
  • Despite differences in presentation and inflammatory markers, outcomes are similar, emphasizing the need for awareness.
Abstract

Keywords:
EmbolismInfective endocarditisMural vegetations

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

1.8K
Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

7.8K

Related Concept Videos

Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
28
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
31
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
45
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
44
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
83
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
62