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Functional mechanism and clinical implications of miR-141 in human cancers

Qi-Qi Luo1, Yu Tian1, Guang-Jin Qu1

  • 1Department of Gerontology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China.

Cellular Signalling
|May 13, 2022
PubMed

Insights

MicroRNAs (miRNAs) regulate cancer growth. This review highlights miR-141

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Cancer arises from uncontrolled cell growth driven by oncogenic factors.
  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression post-transcriptionally.
  • miRNAs bind to messenger RNA targets, influencing protein production and cellular functions.

Purpose of the Study:

  • To review the multifaceted role of miR-141 in various cancers.
  • To elucidate the regulatory mechanisms and signaling pathways affected by miR-141.
  • To explore the potential of miR-141 as a cancer biomarker and therapeutic target.

Main Methods:

  • Literature review of studies investigating miR-141.
  • Analysis of target gene validation and pathway analysis data.
  • Synthesis of findings on miR-141's function in cancer cell proliferation, apoptosis, invasion, and metastasis.

Main Results:

  • miR-141 functions as either a tumor suppressor or an oncomiR depending on the cancer type.
  • It modulates key cancer-related pathways, including PI3K/AKT and NF-κB signaling.
  • Mechanistic insights reveal miR-141's impact on cellular processes critical to cancer progression.

Conclusions:

  • miR-141 plays a significant, context-dependent role in cancer development and progression.
  • Understanding its regulatory functions provides mechanistic insights into oncogenesis.
  • miR-141 shows promise as a noninvasive biomarker and a potential therapeutic strategy for cancer treatment.
Keywords:
DiagnosisMechanismsSignal pathwaysTherapeuticcancermiR-141

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