Penetration of ciprofloxacin into gynecologic tissues

Penetration of ciprofloxacin into gynecologic tissues has been studied after administration of the following: a single oral dose of 500 mg; a single injection of 100 mg; single intravenous infusions of 200 mg and 300 mg, respectively; and repeated oral doses of 500 mg followed by an infusion of 200 mg. In general, tissue concentrations of ciprofloxacin exceeded the corresponding serum concentrations on average twofold to fivefold, irrespective of the route of administration or the size of the dose. For example, mean tissue and serum concentrations of ciprofloxacin determined 12 hours after administration of a single oral dose of 500 mg were as follows: serum, 0.09 mg/liter; ovary, 0.28 mg/kg; uterus, 0.49 mg/kg; endometrium, 0.23 mg/kg; myometrium, 0.34 mg/kg; and fallopian tube, 0.36 mg/kg. Repeated drug administration did not result in an accumulation of ciprofloxacin in either serum or the tissues studied.