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Use of geriatric assessment in cancer clinical trials: A systematic review

Woojung Lee1, Spencer J Cheng1, Shakira J Grant2

  • 1The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, Department of Pharmacy, University of Washington, USA.

Journal of Geriatric Oncology
|May 13, 2022
PubMed
Abstract

Insights

Geriatric assessment (GA) in cancer clinical trials often examines links between patient deficits and outcomes. Standardizing GA use can improve data for older adults in cancer research.

Area of Science:

  • Geriatric Medicine
  • Oncology
  • Clinical Trials

Background:

  • Older adults represent a significant cancer burden but are underrepresented in clinical trials.
  • Geriatric assessment (GA) can improve clinical evidence for cancer drug efficacy in older populations.

Purpose of the Study:

  • To systematically review the utilization patterns of Geriatric Assessment (GA) in cancer clinical trials.
  • To identify common GA domains assessed and their purposes within these trials.

Main Methods:

  • Systematic review of studies published between January 2010 and January 2020.
  • Extracted data on GA use, study phase, cancer type, and participant demographics from 63 eligible studies.
  • Analyzed 74 reported purposes and 258 assessed GA domains.

Main Results:

  • The primary use of GA was to associate impairments with clinical outcomes (38%).
  • Physical status (23%) and comorbidities (19%) were the most frequently assessed GA domains.
  • Significant heterogeneity was observed in instruments used for assessing physical function and mood.

Conclusions:

  • GA is predominantly used to correlate patient deficits with clinical outcomes in cancer trials.
  • Heterogeneity in GA tools necessitates standardization for consistent data collection.
  • Consistent GA integration can enhance older adult-specific data and improve trial inclusivity.
Keywords:
Cancer clinical trialsGeriatric assessmentOlder adults

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