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SARcopenia Assessment in Hypertension: The SARAH Study.
Murat Kara1, Özgür Kara, Yasin Ceran
1From the Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey (MK, BK, EGK, PA, HO, LÖ); Department of Internal Medicine, Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey (ÖK, TCK, BNÇ, MED, ED, GT); Department of Business and Technology Management, Korea Advanced Institute of Science and Technology, Seoul, South Korea (YC); Combined Military Hospital & Quetta Institute of Medical Sciences, Quetta, Pakistan (SR); Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Ankara, Turkey (YD); Physical Medicine and Rehabilitation Hospital, Andalous, Kuwait (DS, AJA); Department of Physical Medicine and Rehabilitation, Physical Medicine and Rehabilitation Hospital, Andalous, Kuwait (SAA); Department of Physical Medicine and Rehabilitation, Ankara City Hospital, Ankara, Turkey (AMA, FÜM); Department of Physical Medicine and Rehabilitation, University of Health Science, Basaksehir Cam and Sakura City Hospital, İstanbul, Turkey (EC); Department of Physical and Rehabilitation Medicine, Dokuz Eylül University Medical School, İzmir, Turkey (B. Dilek); Department of Physical and Rehabilitation Medicine, Kozan State Hospital, Adana, Turkey (MAC); Department of Physical Medicine and Rehabilitation, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey (PY); Charles University and General University Hospital, Prague, Czech Republic (KM); Department of Physical Medicine and Rehabilitation, University of Health Sciences, Sisli Hamidiye Etfal Teaching and Research Hospital, Istanbul, Turkey (B. Doğu); Department of Physical and Rehabilitation Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey (GK); Department of Physical Medicine and Rehabilitation, Celal Bayar University, Manisa, Turkey (ZÜ); Department of Physical Medicine and Rehabilitation, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal (JB, SP); Department of Physical Medicine and Rehabilitation, İstanbul University-Cerrahpaşa Cerrahpaşa School of Medicine, İstanbul, Turkey (DP); Department of Physical Medicine and Rehabilitation, Mersin University Faculty of Medicine, Mersin, Turkey (OG); Department of Neurology, Stanford University, Stanford, California (MB); and Division of Epidemiology, Department of Public Health, Hacettepe University Medical School, Ankara, Turkey (BÇ).
Hypertension significantly increases sarcopenia risk. Angiotensin-converting enzyme inhibitors improved muscle function, while angiotensin II receptor blockers enhanced muscle mass and physical performance in females, indicating differential effects of these medications.
Area of Science:
- Gerontology
- Cardiology
- Muscle Physiology
Background:
- Sarcopenia, age-related muscle loss, is a growing concern.
- The renin-angiotensin system plays a role in cardiovascular and renal function.
- The relationship between sarcopenia and renin-angiotensin system disorders requires further investigation.
Purpose of the Study:
- To examine the association between sarcopenia and renin-angiotensin system disorders.
- To evaluate the impact of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) on muscle mass, function, and physical performance.
Main Methods:
- A multicenter, cross-sectional study involving 2613 participants (mean age 61.0 ± 9.5 years).
- Sarcopenia diagnosis utilized the ISarcoPRM algorithm.
- Statistical analyses adjusted for clinical and potential confounders.
Main Results:
- Hypertension was independently associated with a 2-fold increased risk of sarcopenia in both males and females.
- Hypertensive participants exhibited worse sarcopenia-related parameters compared to normotensive individuals.
- In females, ACEI users showed better muscle function but lower muscle mass and gait speed than ARB users.
Conclusions:
- Hypertension is a significant independent predictor of sarcopenia.
- ACEIs and ARBs demonstrate differential effects on muscle mass, function, and physical performance, particularly in females.
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