Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

93.0K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
93.0K
Sanger Sequencing01:57

Sanger Sequencing

758.8K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
758.8K
Septins01:19

Septins

1.9K
Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. In 1971 while studying the cell division cycle in mutant Saccharomyces cerevisiae Harwell et al. first identified the septin-related genes playing a crucial role in yeast cytokinesis. Fluorescence microscopy revealed that these proteins localize at the budding neck as rings. These ring-like proteins were then named Septins by John Pringle, and...
1.9K
Scientific Laws and Theories02:31

Scientific Laws and Theories

81.3K
Scientific Laws
81.3K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

11.6K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
11.6K
Development of Analytical Methods01:21

Development of Analytical Methods

761
An analytical methodology can be divided into four sequential steps: technique, method, procedure, and protocol. A technique is a scientific principle that rationalizes a specific phenomenon through chemical measurements. Adapting a technique for analyzing a sample of interest is termed a method. The procedure outlines the directions for performing the analysis via an analytical method. The protocol is the detailed guidelines on the procedure, which should be strictly followed to obtain the...
761

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Malaria Incidence, Growth, and their Relationship among a Cohort of Malawian Children.

The American journal of tropical medicine and hygiene·2026
Same author

Asymptomatic school-age children carry the majority of transmissible Plasmodium falciparum infections.

Communications medicine·2026
Same author

Incident hypertension among adults on ART in Malawi: a nested cohort study.

BMC infectious diseases·2025
Same author

Predictors and characteristics of malaria treatment-seeking in Malawi: a longitudinal cohort study.

Malaria journal·2025
Same author

Effect of malaria chemoprevention for school-age children across transmission archetypes: a modelling study.

The Lancet. Global health·2025
Same author

Impact of Trimethoprim-Sulfamethoxazole and Chloroquine Prophylaxis on Drug-Resistant Plasmodium falciparum Mutations in Adults with HIV in Malawi.

The American journal of tropical medicine and hygiene·2025

Related Experiment Video

Updated: Sep 23, 2025

Using Generative Art to Convey Past and Future Climate Transitions
06:10

Using Generative Art to Convey Past and Future Climate Transitions

Published on: March 31, 2023

1.1K

RTS,S today and tomorrow's science.

Nginache Nampota Nkomba1, Cristiana Cairo2, Miriam K Laufer3

  • 1Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.

Cell Host & Microbe
|May 13, 2022
PubMed
Summary
This summary is machine-generated.

The first malaria vaccine offers hope for children in endemic areas. However, its moderate effectiveness necessitates further research to improve malaria prevention strategies.

More Related Videos

A Flexible Chamber for Time-Lapse Live-Cell Imaging with Stimulated Raman Scattering Microscopy
07:40

A Flexible Chamber for Time-Lapse Live-Cell Imaging with Stimulated Raman Scattering Microscopy

Published on: August 31, 2022

1.4K
Large Scale Energy Efficient Sensor Network Routing Using a Quantum Processor Unit
05:30

Large Scale Energy Efficient Sensor Network Routing Using a Quantum Processor Unit

Published on: September 8, 2023

672

Related Experiment Videos

Last Updated: Sep 23, 2025

Using Generative Art to Convey Past and Future Climate Transitions
06:10

Using Generative Art to Convey Past and Future Climate Transitions

Published on: March 31, 2023

1.1K
A Flexible Chamber for Time-Lapse Live-Cell Imaging with Stimulated Raman Scattering Microscopy
07:40

A Flexible Chamber for Time-Lapse Live-Cell Imaging with Stimulated Raman Scattering Microscopy

Published on: August 31, 2022

1.4K
Large Scale Energy Efficient Sensor Network Routing Using a Quantum Processor Unit
05:30

Large Scale Energy Efficient Sensor Network Routing Using a Quantum Processor Unit

Published on: September 8, 2023

672

Area of Science:

  • Malariology
  • Vaccinology
  • Pediatric Infectious Diseases

Background:

  • The recent approval of the first malaria vaccine marks a significant milestone in global health.
  • Malaria remains a major cause of childhood mortality in endemic regions.
  • The vaccine's development addresses a critical unmet need in malaria control.

Purpose of the Study:

  • To evaluate the anticipated impact of the newly approved malaria vaccine.
  • To identify key areas for ongoing clinical and basic science research.
  • To guide future efforts in enhancing malaria vaccine efficacy and implementation.

Main Methods:

  • Review of existing clinical trial data on vaccine efficacy and safety.
  • Analysis of epidemiological trends in malaria-endemic regions.
  • Consultation with experts in vaccinology and tropical medicine.

Main Results:

  • The vaccine demonstrates a modest but significant reduction in malaria incidence.
  • Real-world impact will depend on factors like coverage, strain efficacy, and booster schedules.
  • Significant gaps remain in understanding long-term protection and optimal usage.

Conclusions:

  • The current malaria vaccine is a valuable tool but not a complete solution.
  • Continued investment in clinical research is crucial for optimizing vaccine performance.
  • Basic science research is essential for developing next-generation malaria vaccines with higher efficacy.