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Author Spotlight: Advancements in Nanoparticle Technology for Drug Delivery and Immunotherapy

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Published on: November 10, 2023

Split bullets loaded nanoparticles for amplified immunotherapy.

Chendong Liu¹, Lian Li¹, Jiayan Lyu¹

¹Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|May 13, 2022

Summary

This study introduces a novel nanoplatform that dual-targets tumor cell mitochondria and endoplasmic reticulum. This approach enhances dendritic cell (DC) function, boosting antitumor immunity and establishing long-term immune memory.

Keywords:

Dendritic cell Endoplasmic reticulum Immunotherapy Mitochondria Nanoparticle

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Area of Science:

Immunology
Nanotechnology
Cancer Therapy

Background:

Dendritic cells (DCs) are crucial for adaptive antitumor immunity.
Tumor microenvironments often suppress DC function, limiting therapeutic efficacy.
Existing immunotherapies face challenges due to low tumor immunogenicity.

Purpose of the Study:

To develop a nanoplatform capable of dual subcellular targeting within tumor cells.
To enhance dendritic cell recruitment and activation for improved antitumor responses.
To establish a generalizable strategy for augmenting cancer immunotherapy.

Main Methods:

Development of a "split bullets" loaded nanoplatform.
Mitochondria (MT)-targeted component triggers ATP release, recruiting peripheral DCs.
Endoplasmic reticulum (ER)-targeted component activates tumor-infiltrating DCs via calreticulin exposure.

Main Results:

The nanoplatform effectively targets both mitochondria and endoplasmic reticulum in tumor cells.
Dual targeting enhances DC tropism and reactivity to tumor-specific antigens.
Treatment suppressed primary melanoma and established systemic immune memory against recurrence.

Conclusions:

The developed nanoplatform offers a novel strategy to enhance dendritic cell function.
This approach shows promise in boosting antitumor immunity and overcoming treatment resistance.
The nanoplatform provides a generalizable method for improving cancer immunotherapy outcomes.