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Updated: Sep 23, 2025

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

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Usefulness of 18F-FDG PET/computed tomography in differentiating between subacute and chronic aortic dissection:

Takatoshi Higashigawa1, Yasutaka Ichikawa1, Shuji Chino2

  • 1Department of Radiology, Mie University Hospital, Edobashi, Tsu.

Nuclear Medicine Communications
|May 13, 2022
PubMed

Insights

18F-FDG PET/CT effectively distinguishes subacute from chronic aortic dissection (AD) in patients with unknown onset. This metabolic assessment aids in determining appropriate treatment indications for AD.

Area of Science:

  • Cardiovascular Imaging
  • Nuclear Medicine
  • Radiology

Background:

  • Distinguishing subacute from chronic aortic dissection (AD) is crucial for thoracic endovascular repair selection.
  • Reliable methods for differentiating AD phases in unknown onset cases are lacking.

Purpose of the Study:

  • To evaluate the diagnostic performance of 2-[18F] fluoro-2-deoxy-d-glucose (18F-FDG)-PET/computed tomography (PET/CT).
  • To discriminate between subacute and chronic AD using 18F-FDG PET/CT.

Main Methods:

  • Thirteen medically treated AD patients underwent 18F-FDG PET/CT scans in subacute and 6-month follow-up phases.
  • Target-to-background ratio (TBR) was calculated using maximum standardized uptake value (SUV) in the dissected aortic wall and blood pool SUV.

Main Results:

  • TBR was significantly higher in the subacute phase (1.97 ± 0.32) compared to the chronic phase (1.69 ± 0.29).
  • The area under the receiver operating characteristic curve for TBR was 0.76.
  • A TBR threshold of 1.74 achieved 85% sensitivity and 69% specificity for discriminating subacute from chronic AD.

Conclusions:

  • 18F-FDG PET/CT provides a useful metabolic assessment of the dissected aortic wall.
  • This imaging modality aids in differentiating subacute from chronic AD.
  • It offers valuable information for treatment indication in AD patients with unknown onset.
Abstract

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