Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Intravenous insulin infusions in rats decrease gustatory-evoked responses to sugars.

B K Giza, T R Scott

The American Journal of Physiology

|May 1, 1987

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A comparative examination of thrombocyte/platelet immunity.

Immunology letters·2014

Same author

Atovaquone and proguanil hydrochloride for prophylaxis of malaria.

Journal of travel medicine·2013

Same author

Command and control interfaces for advanced neuroprosthetic applications.

Neuromodulation : journal of the International Neuromodulation Society·2011

Same author

Effect of stress on carnosine levels in brain, breast, and thigh of broilers.

Poultry science·2011

Same author

A colorimetric method for the determination of uranium in leach liquors.

The Analyst·2010

Same author

Influence of supramammary lymph node extract on in vitro cell proliferation.

Cell proliferation·2008

Same journal

Blood coagulation in fish.

The American journal of physiology·2011

Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010

Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010

Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010

Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010

Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010

See all related articles

Physiological doses of insulin reduce the brain

Area of Science:

Neuroscience
Physiology
Endocrinology

Background:

Physiological factors significantly influence food intake and central nervous system activity.
Insulin exhibits a bimodal effect on feeding: inhibitory at physiological levels and hyperphagic at higher doses.

Purpose of the Study:

To investigate the impact of low-dose intravenous insulin on taste-evoked neural responses.
To determine how insulin affects neural processing of different taste stimuli in rats.

Main Methods:

Rats received low intravenous doses of regular insulin (0.5 U/kg) or a control vehicle.
Taste responses to glucose, fructose, NaCl, HCl, and quinine were recorded in the nucleus tractus solitarius.
Neural activity was monitored before and after insulin or vehicle administration.

Related Experiment Videos

Main Results:

Insulin significantly suppressed taste responsiveness to glucose and fructose between 7 and 22 minutes post-injection.
Neural responses to NaCl, HCl, and quinine remained unaffected by insulin.
A reduction in sweet taste appeal may be mediated by insulin's effect on neural processing.

Conclusions:

Physiological doses of insulin can reduce the hedonic appeal of sweet tastes by altering neural responses.
This suppression of sweet taste responsiveness may represent a mechanism for insulin-induced feeding reduction.
The findings link insulin's metabolic effects to central taste processing and feeding behavior.