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Association between vascular calcification in intracranial vertebrobasilar circulation and luminal stenosis

Shivaprakash B Hiremath1, Undrakh-Erdene Erdenebold1, Mario Kontolemos1

  • 1Department of Radiology, Division of Neuroradiology, University of Ottawa, The Ottawa Hospital Civic and General Campus, 1053 Carling Avenue, Ottawa, ON, K1Y 4E9, Canada.

Neuroradiology
|May 13, 2022
PubMed

Insights

Vascular calcification moderately correlates with luminal stenosis in the vertebrobasilar circulation. However, high calcium burden does not predict severe stenosis, even with circumferential calcification.

Area of Science:

  • Neurology
  • Radiology
  • Cardiovascular Medicine

Background:

  • Vascular calcification is a common finding in patients with cerebrovascular disease.
  • Understanding the relationship between calcification and stenosis is crucial for risk stratification.

Purpose of the Study:

  • To assess the correlation between calcium burden and luminal stenosis in the vertebrobasilar circulation.
  • To investigate if higher calcium burden predicts severe stenosis.

Main Methods:

  • 166 stroke patients underwent non-contrast CT (NCCT), CT perfusion (CTP), and CT angiography (CTA).
  • Quantitative calcium burden (Agatston-Janowitz score, volume, mass) and luminal stenosis were measured.
  • Correlation coefficients were calculated between calcium burden and stenosis measures.

Main Results:

  • 45.8% of arteries showed calcification; 33.9% had measurable stenosis.
  • Moderate correlations were found between calcium burden and luminal stenosis (qualitative and quantitative).
  • Higher calcium burden and circumferential calcification did not correlate with severe stenosis.

Conclusions:

  • A moderate association exists between vascular calcification burden and luminal stenosis severity.
  • Severe luminal stenosis was not observed even with advanced calcification patterns.
Abstract

Keywords:
AtherosclerosisCT angiographyStenosisStrokeVertebrobasilar circulation

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