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Related Experiment Videos

Provoked asthma and mast cells.

A B Kay

    The American Review of Respiratory Disease
    |May 1, 1987
    PubMed
    Summary

    Asthma pathogenesis involves mediators, with mast cells likely playing a role. Further research using bronchoscopy is needed to understand mast cell mediators and their impact on asthma.

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    Area of Science:

    • Immunology
    • Pulmonology
    • Allergy

    Background:

    • Asthma pathogenesis involves early and late-phase responses.
    • Mediators are implicated in asthma development.
    • Mast cell activation is suggested by histamine detection.

    Purpose of the Study:

    • To investigate the role of mast cells and their mediators in asthma.
    • To clarify the origin of non-classical mediators (NCA).
    • To explore the necessity of invasive procedures for accurate data.

    Main Methods:

    • Detection of histamine in early- and late-phase asthma.
    • Analysis of mast cell involvement and mediator roles.
    • Consideration of fiberoptic bronchoscopy for direct lung analysis.

    Main Results:

    • Histamine presence suggests mast cell activation in allergen- and exercise-induced asthma.
    • The origin of NCA remains uncertain, possibly from other cell types.
    • Mast cell involvement may be secondary or amplifying, not primary.

    Conclusions:

    • Substantial evidence implicates mediators in asthma pathogenesis.
    • Further investigation into prostaglandins and leukotrienes is crucial.
    • Fiberoptic bronchoscopy may provide critical insights into mast cell activity and drug effects in asthma.

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