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Antibiotic Selection

Antibiotic Selection

Guidelines for Nursing Documentation I

Guidelines for Nursing Documentation I

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Factual:
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Antimicrobial Effectiveness

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

Pharmacovigilance

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Guidelines for Nursing Documentation II

Guidelines for Nursing Documentation II

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Healthcare Associated Infections II: Preventive Measures

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Related Experiment Video

Updated: Sep 23, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Documenting the indication for antimicrobial prescribing: a scoping review.

Sharon Saini¹, Valerie Leung^2,3, Elizabeth Si¹

¹Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

BMJ Quality & Safety

|May 13, 2022

Summary

Documenting antimicrobial indications is crucial for best practice. Evidence shows this practice improves prescribing and patient outcomes, though more research is needed for widespread implementation.

Keywords:

antibiotic management general practice healthcare quality improvement implementation science medication safety

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Area of Science:

Antimicrobial stewardship
Health services research
Clinical documentation

Background:

Documenting the indication for antimicrobial prescribing is recognized as a best practice.
However, a comprehensive understanding of the supporting evidence is needed to promote its wider adoption.

Purpose of the Study:

To conduct a scoping review evaluating antimicrobial indication documentation.
The review focused on its implementation, prevalence, accuracy, and impact on clinical and utilization outcomes across all patient populations.

Main Methods:

A systematic search of multiple databases (MEDLINE, Embase, CINAHL, International Pharmaceutical Abstracts) and grey literature was performed.
Two independent reviewers screened and extracted data from 123 included studies, categorizing them inductively and presenting results descriptively.

Main Results:

The median prevalence of antimicrobial indication documentation was 75% (range 4%-100%), with most studies (89%) conducted in hospital settings.
Of 19 studies examining impact, 17 found benefits to prescribing or patient outcomes.
Ten qualitative studies identified common barriers and facilitators to documentation.

Conclusions:

Antimicrobial indication documentation is increasingly recognized for its importance.
Emerging evidence links this practice to improved prescribing and patient outcomes in both community and hospital settings.
Further setting-specific and larger trials are necessary to strengthen the evidence base.