Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal and abnormal bone remodeling in man.

R Marcus

    Annual Review of Medicine
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Bone remodeling, a lifelong process of skeletal renewal, contributes to age-related bone loss. Understanding this process is key to treating metabolic bone diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    What do South African adolescents want in a sexual health service? Evidence from the South African Studies on HIV in Adolescents (SASHA) project.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2018
    Same author

    Comments on Galli et al.: The effect of magnesium on early osseointegration in osteoporotic bone: a histological and gene expression investigation.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
    Same author

    High-dose chemotherapy and autologous stem cell transplantation for primary central nervous system lymphoma: a multi-centre retrospective analysis from the United Kingdom.

    Bone marrow transplantation·2017
    Same author

    Remission Induction in Patients with Lymphoid Malignancies Using Unconjugated CAMPATH-1 Monoclonal Antibodies.

    Leukemia & lymphoma·2016
    Same author

    Response and remission rates with adjunctive aripiprazole in patients with major depressive disorder who exhibit minimal or no improvement on antidepressant monotherapy.

    International journal of clinical practice·2014
    Same author

    Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

    Annals of oncology : official journal of the European Society for Medical Oncology·2014
    Same journal

    Dupilumab Emerges as an Effective Antibody Therapy for Eosinophilic Esophagitis.

    Annual review of medicine·2026
    Same journal

    CAR T Cell Toxicities and Emerging Treatment Strategies.

    Annual review of medicine·2026
    Same journal

    Transthyretin Amyloid Cardiomyopathy: A Rapidly Evolving Landscape.

    Annual review of medicine·2026
    Same journal

    Accessibility of Somatic Genetic Testing for Cancer Treatment Decisions.

    Annual review of medicine·2026
    Same journal

    Diffuse Parenchymal Lung Disease: Updates in Pathophysiology and Management.

    Annual review of medicine·2026
    Same journal

    Revascularization for Ischemic Cardiomyopathy: Disproving the 45-Year-Old Concept of Hibernating Myocardium.

    Annual review of medicine·2026
    See all related articles

    Area of Science:

    • Skeletal Biology
    • Bone Physiology
    • Mammalian Anatomy

    Background:

    • Bone remodeling is a continuous cycle of bone resorption and formation.
    • This essential process maintains skeletal integrity but contributes to age-related bone loss.
    • Factors like diet and hormones influence bone mass by altering remodeling rates.

    Purpose of the Study:

    • To explain the fundamental mechanisms of bone remodeling.
    • To highlight the role of remodeling in normal aging and bone loss.
    • To underscore the importance of understanding remodeling for metabolic bone disease therapy.

    Main Methods:

    • Review of existing literature on bone remodeling.
    • Analysis of factors influencing skeletal renewal.
    • Conceptual framework for understanding bone mass regulation.

    Related Experiment Videos

    Main Results:

    • Bone remodeling is an inherent, albeit inefficient, process in mammals.
    • Age-related bone loss is a consequence of remodeling's fundamental inefficiency.
    • Bone mass changes result from alterations in the rate of new remodeling units or imbalance within existing units.

    Conclusions:

    • Understanding bone remodeling is crucial for diagnosing and treating metabolic bone diseases.
    • The inefficiency of remodeling is a primary driver of age-related bone loss.
    • Therapeutic strategies for bone diseases must consider the dynamics of remodeling units.