Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone lead measurements in patients with chronic renal disease studied over time.

Archives of environmental health·1992
Same author

Repeated bone lead levels in Queensland, Australia--previously a high lead environment.

Archives of environmental health·1992
Same author

The parathyroid glands in chronic renal failure: a study of their growth and other properties made on the basis of findings in patients with hypercalcemia.

The Journal of laboratory and clinical medicine·1989
Same author

Patterns of lead excretion in patients with gout and chronic renal failure--a comparative German and Australian study.

The Science of the total environment·1987
Same author

Assessment of a two-step high-performance liquid chromatographic assay using dual-wavelength ultraviolet monitoring for 25-hydroxyergocalciferol and 25-hydroxycholecalciferol in human serum or plasma.

Journal of chromatography·1986
Same author

Chronic lead nephropathy in Queensland: alternative methods of diagnosis.

Australian and New Zealand journal of medicine·1986

Related Experiment Video

Updated: Jun 23, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Chronic lead nephropathy.

P W Craswell

    Annual Review of Medicine
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Chronic lead nephropathy is an underdiagnosed cause of kidney disease, particularly in industrial areas. Current diagnostic methods for lead body burden are inefficient, hindering timely diagnosis and treatment.

    More Related Videos

    The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
    07:27

    The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

    Published on: October 21, 2017

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
    05:34

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

    Published on: April 4, 2025

    Related Experiment Videos

    Last Updated: Jun 23, 2026

    5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
    08:50

    5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

    Published on: July 3, 2013

    The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
    07:27

    The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

    Published on: October 21, 2017

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
    05:34

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

    Published on: April 4, 2025

    Area of Science:

    • Nephrology
    • Environmental Health
    • Toxicology

    Background:

    • Chronic lead nephropathy is a significant contributor to kidney disease and mortality globally, especially in industrial regions.
    • Underdiagnosis of lead nephropathy stems from its infrequent consideration in chronic renal disease differential diagnoses.
    • Existing methods for assessing lead body burden are often impractical due to being cumbersome, time-consuming, and potentially inaccurate.

    Purpose of the Study:

    • To highlight the underdiagnosis of chronic lead nephropathy.
    • To underscore the limitations of current lead body burden assessment methods.
    • To emphasize the need for improved diagnostic approaches for lead-induced kidney damage.

    Main Methods:

    • Review of existing literature on lead nephropathy diagnosis and body burden assessment.
    • Analysis of diagnostic challenges in clinical settings.
    • Discussion of the shortcomings of current lead toxicity testing.

    Main Results:

    • Chronic lead nephropathy is frequently overlooked in patients with chronic kidney disease.
    • Established methods for measuring lead body burden present significant practical challenges.
    • Inaccuracy and inefficiency of current tests impede the identification of lead as a causative factor in renal disease.

    Conclusions:

    • There is a critical need to improve the recognition of chronic lead nephropathy in clinical practice.
    • Development of more accessible and accurate methods for assessing lead body burden is essential.
    • Enhanced diagnostic strategies are required to address the underdiagnosis of lead-induced kidney disease.