Simultaneous high-resolution T₂ -weighted imaging and quantitative T₂ mapping at low magnetic field strengths using a...

Low magnetic field systems provide an important opportunity to expand MRI to new and diverse clinical and research study populations. However, a fundamental limitation of low field strength systems is the reduced SNR compared to 1.5 or 3T, necessitating compromises in spatial resolution and imaging time. Most often, images are acquired with anisotropic voxels with low through-plane resolution, which provide acceptable image quality with reasonable scan times, but can impair visualization of subtle pathology.

Here, we describe a super-resolution approach to reconstruct high-resolution isotropic T₂ -weighted images from a series of low-resolution anisotropic images acquired in orthogonal orientations. Furthermore, acquiring each image with an incremented TE allows calculations of quantitative T₂ images without time penalty.

Our approach is demonstrated via phantom and in vivo human brain imaging, with simultaneous 1.5 × 1.5 × 1.5 mm³ T₂ -weighted and quantitative T₂ maps acquired using a clinically feasible approach that combines three acquisition that require approximately 4-min each to collect. Calculated T₂ values agree with reference multiple TE measures with intraclass correlation values of 0.96 and 0.85 in phantom and in vivo measures, respectively, in line with previously reported brain T₂ values at 150 mT, 1.5T, and 3T.

Our multi-orientation and multi-TE approach is a time-efficient method for high-resolution T₂ -weighted images for anatomical visualization with simultaneous quantitative T₂ imaging for increased sensitivity to tissue microstructure and chemical composition.