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Updated: Sep 23, 2025

Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
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apCAFs Are Derived from Mesothelial Cells and Induce Regulatory T Cells

    Cancer Discovery
    |May 13, 2022
    PubMed

    Insights

    Antigen-presenting cancer-associated fibroblasts (apCAFs) originate from mesothelial cells. This finding reveals a new cellular origin for apCAFs in cancer research.

    Area of Science:

    • Oncology
    • Cell Biology
    • Immunology

    Background:

    • Cancer-associated fibroblasts (CAFs) play a crucial role in tumor microenvironment.
    • The cellular origins of different CAF subtypes are not fully understood.

    Purpose of the Study:

    • To investigate the cellular origin of antigen-presenting cancer-associated fibroblasts (apCAFs).

    Main Methods:

    • Utilized lineage tracing and single-cell RNA sequencing.
    • Analyzed markers of mesothelial cells and apCAFs.

    Main Results:

    • Demonstrated that apCAFs are derived from mesothelial cells.
    • Identified specific markers for tracing this cellular transition.

    Conclusions:

    • Mesothelial cells represent a novel source for apCAF generation.
    • Understanding apCAF origin may offer new therapeutic targets in cancer.

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