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Related Experiment Video

Updated: Sep 23, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Altered cortical structure network in children with obstructive sleep apnea.

Min-Hee Lee1, Sanghun Sin2, Seonjoo Lee3

  • 1Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.

Sleep
|May 13, 2022
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Summary

Children with obstructive sleep apnea (OSA) show altered brain network organization. This study reveals differences in cortical structure and connectivity in pediatric OSA patients compared to controls.

Keywords:
T1-weighted imagingchildren with obstructive sleep apneacortical structure networkcortical thickness

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Area of Science:

  • Neuroscience
  • Pediatric Neurology
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) involves recurrent airway collapse during sleep.
  • This leads to intermittent hypoxia and sleep fragmentation.
  • These factors may alter brain structure and function.

Purpose of the Study:

  • To investigate if obstructive sleep apnea in children reorganizes cortical structure.
  • To examine changes in cortical thickness correlation between brain regions in pediatric OSA.
  • To understand the etiology of OSA-related brain functional disorders.

Main Methods:

  • Cortical structure networks were constructed using cortical thickness measurements.
  • Data from 41 controls and 50 children with OSA were analyzed.
  • Global (clustering coefficient, path length, small-worldness) and regional (nodal betweenness centrality) network properties were examined.

Main Results:

  • Children with OSA exhibited increased clustering coefficients compared to controls.
  • Lower nodal betweenness centrality was observed in specific left and right hemisphere regions in the OSA group.
  • The OSA group had fewer and differently distributed brain network hubs.

Conclusions:

  • Pediatric OSA is associated with altered global and regional cortical network characteristics.
  • The findings suggest potential structural brain reorganization in children with OSA.
  • This network analysis approach may aid in understanding OSA-related neurological impacts.