Related Experiment Video

Updated: Sep 23, 2025

Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach
13:57

Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach

Published on: May 23, 2025

467

Short-term outcomes of patients with chronic liver disease hospitalised with COVID-19

Ivica Grgurevic1,2,3, Marko Lucijanić2,4, Frane Pastrovic1

  • 1Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia.

Internal Medicine Journal
|May 13, 2022
PubMed

Insights

Patients with cirrhosis hospitalized for COVID-19 face significantly higher mortality risks. This study highlights cirrhosis as an independent predictor of poor outcomes in COVID-19 patients.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Chronic liver disease (CLD) may worsen COVID-19 outcomes.
  • Understanding COVID-19 impact on CLD patients is crucial.

Purpose of the Study:

  • To analyze the outcomes of hospitalized COVID-19 patients with CLD.
  • To identify risk factors for mortality in this population.

Main Methods:

  • Retrospective analysis of 4014 COVID-19 hospitalizations over 12 months.
  • Identification of CLD and cirrhosis patients using ICD-10 codes.
  • 30-day follow-up for ICU admission, mechanical ventilation, and death.

Main Results:

  • 110 patients (2.7%) had CLD; 49 (1.2%) had cirrhosis.
  • Cirrhosis patients had higher 30-day mortality (45% vs. 73% in matched controls).
  • Liver cirrhosis independently predicted a fourfold higher adjusted risk of 30-day mortality.

Conclusions:

  • Cirrhosis is a significant independent risk factor for mortality in hospitalized COVID-19 patients.
  • CLD alone, without cirrhosis, did not predict worse survival.
Abstract

Keywords:
COVID-19chronic liver diseaseliver cirrhosismortalityprognosis

More Related Videos

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model06:45

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Published on: January 19, 2024

817
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.5K

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
157
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
133
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
464
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
467
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
114
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
219