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Related Experiment Video

Updated: Sep 23, 2025

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

Published on: November 10, 2015

Structural connectivity mapping in human hippocampal-subfields using super-resolution hybrid diffusion imaging: a

Nahla M H Elsaid^1,2, Pierrick Coupé³, Andrew J Saykin^4,5

¹Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. nahla.elsaid@yale.edu.

|May 13, 2022

Summary

This summary is machine-generated.

New hybrid diffusion imaging (HYDI) MRI methods reveal reduced structural integrity in the hippocampus of older adults. This finding offers a new framework for studying brain aging and dementia.

Keywords:

Diffusion imaging Hippocampal subfields Normal aging Structural connectivity Super-resolution

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Last Updated: Sep 23, 2025

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Published on: November 10, 2015

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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

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Published on: August 14, 2019

Area of Science:

Neuroimaging
Gerontology
Structural MRI

Background:

Aging affects cognitive functions, with the hippocampus being particularly vulnerable.
Understanding age-related changes in hippocampal connectivity is crucial for diagnosing and treating neurodegenerative diseases.

Purpose of the Study:

Introduce a novel super-resolution hybrid diffusion imaging (HYDI) methodology for hippocampus-aging research.
Utilize HYDI MRI to investigate age-related alterations in hippocampal structure and connectivity.

Main Methods:

Acquired HYDI diffusion data from young and older healthy adults.
Transformed data into super-resolution images for detailed hippocampal subfield analysis.
Examined correlations between age, hippocampal subfield connectivity, and whole-brain connectivity.

Main Results:

Older adults exhibited reduced structural integrity in tractography streamlines between hippocampal subfields compared to younger adults.
Demonstrated age-related decline in the structural connectivity within the hippocampus.

Conclusions:

The developed HYDI MRI methodology provides a promising framework for aging and hippocampus studies.
Findings open avenues for future research into the relationship between hippocampal connectivity and dementia.