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SS18-SSX drives CREB activation in synovial sarcoma.
Magdalene Cyra1,2, Miriam Schulte1,2, Ruth Berthold1,2
1Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, Münster University Hospital, Münster, Germany.
Cellular Oncology (Dordrecht, Netherlands)
|May 13, 2022
Summary
The transcription factor CREB is activated in synovial sarcoma (SySa) and drives tumor growth. Inhibiting CREB shows promise for targeted SySa therapies.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Genetics
Background:
- Synovial sarcoma (SySa) is a rare soft tissue tumor driven by the SS18-SSX fusion protein.
- The precise oncogenic mechanisms of SS18-SSX and targeted therapeutic strategies for SySa are not fully understood.
Purpose of the Study:
- To investigate the functional and therapeutic relevance of the transcription factor CREB in SySa tumorigenesis.
- To explore CREB as a potential molecular target for SySa treatment.
Main Methods:
- Immunohistochemistry of phosphorylated CREB and downstream targets in a SySa cohort.
- In vitro analysis of CREB activity in SySa cell lines and mesenchymal stem cells.
- In vivo studies using avian and murine models to assess CREB inhibition efficacy.
Main Results:
- CREB is phosphorylated and activated in SySa, with its expression linked to SS18-SSX.
- SS18-SSX expression promotes CREB activation, while its knockdown impairs CREB phosphorylation.
- CREB inhibition suppressed SySa cell proliferation and induced apoptosis in vitro and in vivo.
Conclusions:
- CREB plays an essential role in SySa tumorigenesis.
- Targeting CREB represents a promising molecular strategy for synovial sarcoma therapy.
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