Antibiotic prophylaxis for prostatic surgery. Single-dose cephradine compared with single-dose cefotaxime

Area of Science:

• Urology
• Infectious Diseases
• Pharmacology

Background:

• Antibiotic prophylaxis is crucial for reducing infection risk in prostatic surgery.
• Previous studies support the use of prophylactic antibiotics for these procedures.

Purpose of the Study:

• To compare the efficacy of single-dose cefotaxime versus cephradine for antibiotic prophylaxis in prostatic surgery.
• To assess the long-term impact of antibiotic prophylaxis on ward flora and bacterial resistance over a 5-year period.

Main Methods:

• A prospective randomized study comparing single-dose cefotaxime and cephradine at anesthesia induction.
• A 5-year survey of ward flora to monitor for changes in bacterial susceptibility.

Main Results:

• No significant difference was observed between cefotaxime and cephradine regimens.
• The 5-year survey revealed no significant changes in ward flora or emergence of resistant bacterial strains.

Conclusions:

• Either cefotaxime or cephradine can be used for antibiotic prophylaxis in prostatic surgery, based on availability and cost.
• Current antibiotic prophylaxis strategies have not led to the emergence of resistant strains in the studied ward flora.