Prescribed drugs containing nitrogen heterocycles: an overview
Majid M Heravi1, Vahideh Zadsirjan1
1Department of Chemistry, School of Science, Alzahra University PO Box 1993891176, Vanak Tehran Iran mmh1331@yahoo.com mmheravi@alzahra.ac.ir +98 21 88041344 +98 21 88044051.
Abstract:
Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all biologically active compounds are heterocycles or comprise a heterocycle and most frequently, nitrogen heterocycles as a backbone in their complex structures. These facts disclose and emphasize the vital role of heterocycles in modern drug design and drug discovery. In this review, we try to present a comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways. It is worth mentioning that the reported examples are actually limited to current top selling drugs, being or containing N-heterocycles and their synthetic information has been extracted from both scientific journals and the wider patent literature.
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