Proteomics in Biomarker Discovery for Tuberculosis: Current Status and Future Perspectives

Area of Science:

• Proteomics and Mass Spectrometry
• Biomarker Discovery
• Infectious Diseases

Background:

• Tuberculosis (TB) remains a global health threat, with current diagnostic methods being time-consuming and culture-dependent.
• There is a critical need for more efficient and accurate diagnostic biomarkers for TB.
• Proteomics, the study of proteins, is emerging as a powerful tool for identifying novel disease biomarkers.

Purpose of the Study:

• To review the current applications and future potential of proteomics in TB biomarker discovery.
• To highlight the role of mass spectrometry (MS) and related technologies in advancing TB diagnostics.
• To discuss the challenges and discrepancies in current proteomic biomarker research for TB.

Main Methods:

• Systematic review of literature on proteomics and TB biomarker discovery.
• Focus on mass spectrometry (MS) and its derivative strategies.
• Analysis of advancements in matrix-based and immune-based proteomic methods.

Main Results:

• Proteomics has identified promising protein biomarkers for TB diagnosis.
• Mass spectrometry-based approaches are revolutionizing disease biomarker discovery.
• Discrepancies in identified biomarkers and diagnostic accuracy remain significant challenges.

Conclusions:

• Proteomics holds significant promise for developing rapid and accurate TB diagnostic tools.
• Further research is needed to overcome current challenges and validate proteomic biomarkers for clinical use.
• Continued technological advancements in MS will drive future discoveries in TB diagnostics.