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The Interaction Between Autophagy and JAK/STAT3 Signaling Pathway in Tumors

Jiangyan Xu1, Jinrong Zhang2, Qi-Fen Mao3

  • 1Department of Laboratory Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in Genetics
|May 13, 2022
PubMed

Insights

Autophagy and the JAK/STAT3 signaling pathway are crucial in tumor development. Their complex interplay influences cancer progression, offering potential therapeutic targets for novel tumor treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cellular Metabolism

Background:

  • Tumors pose significant threats to human health, prompting extensive research into their underlying mechanisms.
  • Autophagy and the Janus Kinase/Signal Transducer and Activator of Transcription 3 (JAK/STAT3) signaling pathway are key areas of investigation in cancer research.

Purpose of the Study:

  • To review recent advancements concerning the interaction between autophagy and the JAK/STAT3 signaling pathway in cancer.
  • To explore the roles of this interaction in tumor pathogenesis, prevention, diagnosis, and treatment.

Main Methods:

  • Literature review of current research on autophagy and JAK/STAT3 signaling in oncological studies.
  • Analysis of the synergistic or antagonistic roles of these pathways in tumor development.

Main Results:

  • The JAK/STAT3 pathway regulates critical cellular processes like proliferation, apoptosis, and angiogenesis, making it a viable therapeutic target.
  • Autophagy, a cellular degradation process, plays multifaceted roles in tumor development.
  • Altered STAT3 expression is frequently associated with abnormal autophagy, suggesting a complex relationship.

Conclusions:

  • The interplay between autophagy and the JAK/STAT3 pathway is complex, potentially promoting or inhibiting tumor progression.
  • Understanding this interaction is vital for developing effective tumor therapies targeting these pathways.
Keywords:
JAK/STAT3autophagyinteractionregulationtumor

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