A comparison of full model specification and backward elimination of potential confounders when estimating marginal...

A common view in epidemiology is that automated confounder selection methods, such as backward elimination, should be avoided as they can lead to biased effect estimates and underestimation of their variance. Nevertheless, backward elimination remains regularly applied. We investigated if and under which conditions causal effect estimation in observational studies can improve by using backward elimination on a prespecified set of potential confounders. An expression was derived that quantifies how variable omission relates to bias and variance of effect estimators. Additionally, 3960 scenarios were defined and investigated by simulations comparing bias and mean squared error (MSE) of the conditional log odds ratio, log(cOR), and the marginal log risk ratio, log(mRR), between full models including all prespecified covariates and backward elimination of these covariates. Applying backward elimination resulted in a mean bias of 0.03 for log(cOR) and 0.02 for log(mRR), compared to 0.56 and 0.52 for log(cOR) and log(mRR), respectively, for a model without any covariate adjustment, and no bias for the full model. In less than 3% of the scenarios considered, the MSE of the log(cOR) or log(mRR) was slightly lower (max 3%) when backward elimination was used compared to the full model. When an initial set of potential confounders can be specified based on background knowledge, there is minimal added value of backward elimination. We advise not to use it and otherwise to provide ample arguments supporting its use.