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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Published on: July 28, 2013

Skeletonized mean diffusivity and neuropsychological performance in relapsing-remitting multiple sclerosis.

Magdalena Chylińska¹, Bartosz Karaszewski¹, Jakub Komendziński¹

¹Department of Adult Neurology, Medical University of Gdańsk, Faculty of Medicine, Gdańsk, Poland.

Brain and Behavior

|May 13, 2022

Summary

Peak width of Skeletonized Mean Diffusivity (PSMD) is linked to cognitive decline and disability in relapsing-remitting multiple sclerosis (RRMS) patients. This novel white matter damage marker shows potential for assessing cognitive function and physical impairment in MS.

Keywords:

DTI MRI PSMD cognition multiple sclerosis

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Area of Science:

Neuroimaging
Neurology
Cognitive Science

Background:

White matter (WM) microstructure damage, assessed by Peak width of Skeletonized Mean Diffusivity (PSMD), is linked to cognitive decline in various WM pathologies.
Relapsing-remitting multiple sclerosis (RRMS) involves WM damage, potentially impacting cognitive function.

Purpose of the Study:

To investigate the association between WM microstructure alterations and cognitive dysfunction in RRMS patients.
To explore PSMD as a potential marker for cognitive impairment and disability in RRMS.

Main Methods:

Utilized tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI) to calculate PSMD.
Assessed 73 RRMS patients undergoing interferon beta (IFN-β) therapy, collecting neuropsychological, clinical, and MRI data (PSMD, WM hypointensities, normalized brain volume).

Main Results:

50.7% of patients were cognitively impaired (CI).
PSMD significantly contributed to performance in the California Verbal Learning Test (CVLT) and semantic fluency.
PSMD, normalized brain volume (NBV), and WM hypointensities were significant contributors to upper extremity disability (9HPT) in cognitively normal (CN) patients.
Education attainment was a significant factor in most cognitive measures.

Conclusions:

PSMD is a significant marker of WM microstructure damage associated with cognitive tasks and upper extremity disability in RRMS.
Further research is needed to establish PSMD's clinical relevance as a marker for cognitive impairment in MS.