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Brain-wide interactions during hippocampal sharp wave ripples.

Noam Nitzan1, Rachel Swanson1, Dietmar Schmitz2,3

  • 1Neuroscience Institute, Langone Medical Center, New York University, New York, NY 10016.

Proceedings of the National Academy of Sciences of the United States of America
|May 13, 2022
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Summary

Sharp wave ripples (SPW-Rs) during disengagement correlate with brain-wide connectivity changes. Their hippocampal origin and magnitude influence downstream brain activity patterns and timing.

Keywords:
memoryreplaysleep

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Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Sharp wave ripples (SPW-Rs) are transient neural events during disengagement.
  • Previous studies characterized SPW-R relationships with specific brain areas.
  • The topographic origins of SPW-Rs and their brain-wide communication patterns remain unclear.

Purpose of the Study:

  • To investigate the high-resolution spatio-temporal relationship between hippocampal SPW-Rs and brain-wide activity.
  • To determine how SPW-R topography influences communication direction and downstream responses.

Main Methods:

  • Analysis of two large, publicly available datasets.
  • Simultaneous high-density silicon probe recordings across the mouse forebrain.
  • Investigated functional connectivity and SPW-R features (incidence, magnitude, topography).

Main Results:

  • SPW-Rs coincide with transient, brain-wide increases in functional connectivity.
  • SPW-R features correlate with slower excitability fluctuations in cortical and subcortical areas.
  • Large-amplitude SPW-Rs are followed by transient silence in extrahippocampal structures, with variations linked to origin and magnitude.

Conclusions:

  • Hippocampal SPW-Rs transiently increase brain-wide functional connectivity.
  • The intrahippocampal origin and magnitude of SPW-Rs dictate downstream activity patterns in extrahippocampal structures.
  • This provides insight into the directionality of hippocampal communication.