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Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

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Updated: Sep 23, 2025

Olfactory Behavioral Testing in the Adult Mouse

Olfactory Behavioral Testing in the Adult Mouse

Published on: January 28, 2009

Pediatric olfactory home testing using regular household items: A cross-over validation study.

Lawrence Jaramillo¹, Andreas van Egmond-Froehlich², David T Liu¹

¹Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Austria.

International Journal of Pediatric Otorhinolaryngology

|May 13, 2022

Summary

This summary is machine-generated.

A new olfactory home test using household items is feasible for children. A German version of the Chemosensory Pleasure Scale for Children (CPS-C(de)) was also successfully introduced.

Keywords:

Anosmia Covid-19 Hyposmia Smell U-sniff

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Area of Science:

Olfactory research
Pediatric sensory testing
Chemosensory perception

Background:

Olfactory dysfunction can impact children's quality of life.
Standardized olfactory testing often requires specialized equipment and trained personnel.
Remote and accessible testing methods are needed for pediatric populations.

Purpose of the Study:

To develop a simple, home-based olfactory test for children using common household items.
To introduce and validate a German version of the Chemosensory Pleasure Scale for Children (CPS-C(de)).
To assess the feasibility and reliability of remote olfactory assessment in a pediatric cohort.

Main Methods:

Development and evaluation of fourteen household items for olfactory identification.
A cross-over study involving 50 children (ages 6-17) using the home test and the Universal Sniff test (U-Sniff) as a gold standard.
Translation and empirical validation of the Chemosensory Pleasure Scale for Children (CPS-C(de)) through back-and-forth translation.

Main Results:

All fourteen household items were identified with high accuracy (mean 93.3% ± 9.5%).
The home olfactory test demonstrated near-identical results to the U-Sniff test (bias = 0.04).
The CPS-C(de) showed comparable results to its original version, with a moderate negative correlation between scores and children's Body Mass Index (r = -0.527, p = 0.003).

Conclusions:

Remote olfactory testing in children utilizing readily available household items is a viable method.
The developed olfactory home test and the validated CPS-C(de) are promising tools for future pediatric olfactory research.