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Spontaneous autoimmune thyroiditis in Bio Breeding/Worcester (BB/W) rat.

M Yanagisawa, Y Hara, K Satoh

    Endocrinologia Japonica
    |December 1, 1986
    PubMed
    Summary

    In Bio Breeding/Worcester (BB/W) rats, lymphocytic thyroiditis (LT) and anti-thyroglobulin antibody (ATA) levels increase with age, independent of diabetes. Glucose metabolism derangements may affect thyroid hormones.

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    Area of Science:

    • Endocrinology
    • Immunology
    • Animal Models

    Background:

    • Spontaneous lymphocytic thyroiditis (LT) and diabetes mellitus occur in Bio Breeding/Worcester (BB/W) rats.
    • Investigating the relationship between LT, diabetes, and related biomarkers is crucial for understanding autoimmune diseases.

    Purpose of the Study:

    • To examine serial changes in plasma anti-thyroglobulin antibody (ATA), thyroid hormones, and blood glucose in BB/W rats.
    • To correlate these levels with histological findings in the thyroid gland.
    • To assess the BB/W rat as a model for human autoimmune conditions.

    Main Methods:

    • Solid-phase enzyme immunoassay was used to measure plasma ATA levels.
    • Thyroid hormones (free 3,5,3'-triiodothyronine [FT3] and total thyroxine [TT4]) and blood glucose were measured.

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  • Incidence of diabetes and LT was recorded across different age groups (5, 11, and 20 weeks).

    • Main Results:

    • Incidence of diabetes and LT increased with age, but showed no direct correlation with each other.
    • Plasma ATA levels significantly increased with age and were higher in rats with LT.
    • Lower FT3, TT4, and FT3/TT4 ratio, along with higher blood glucose, were observed in older rats.

    Conclusions:

    • LT in BB/W rats appears to develop independently of insulitis (diabetes).
    • Both ATA levels and LT incidence rise with age, suggesting age-related autoimmune processes.
    • Altered glucose metabolism might contribute to decreased thyroid hormone levels, and BB/W rats are valuable models for human diabetes and autoimmune thyroiditis.